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Usage

Uses

Used in Organic Synthesis:
5-TERT-BUTYL-2-METHOXYBENZENEBORONIC ACID is used as a reagent in the Suzuki-Miyaura coupling reaction, a method pivotal for the formation of carbon-carbon bonds in organic synthesis. This reaction is widely employed for constructing complex organic molecules and plays a crucial role in the synthesis of pharmaceuticals, agrochemicals, and materials.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-TERT-BUTYL-2-METHOXYBENZENEBORONIC ACID is utilized in the development of novel pharmaceuticals. Its unique structure and functional group contribute to the design and synthesis of new drug candidates, potentially leading to the discovery of innovative treatments for various diseases.
Used in Chemical Biology:
5-TERT-BUTYL-2-METHOXYBENZENEBORONIC ACID is used as a tool in chemical biology to study the interactions between biomolecules and small molecules. The presence of the boronic acid group allows it to form reversible covalent bonds with certain biomolecules, facilitating the investigation of biological processes and the development of targeted therapies.
Used in Materials Science:
This boronic acid derivative is also employed in the development of new materials with specific properties. Its unique chemical structure can be integrated into the design of materials with applications in various industries, such as electronics, energy, and environmental science.
Overall, 5-TERT-BUTYL-2-METHOXYBENZENEBORONIC ACID is a versatile chemical reagent with diverse applications across multiple scientific disciplines, including organic chemistry, medicinal chemistry, chemical biology, and materials science.

InChI:InChI=1/C11H17BO3/c1-11(2,3)8-5-6-10(15-4)9(7-8)12(13)14/h5-7,13-14H,1-4H3

Upstream product

• 5396-38-3 1-(tert-butyl)-4-methoxybenzene 
• 98-54-4 para-tert-butylphenol 
• 2198-66-5 2-bromo-4-tert-butylphenol 
• 1609573-33-2 8-bromo-3,6-di-tert-butyl-3,4-dihydro-2H-benzo[e][1,3]oxazine 
• 5419-55-6 Triisopropyl borate 
• 41280-65-3 2-bromo-4-tert-butylanisole 
• 75060-39-8 4-(tert-butyl)-2-iodo-1-methoxybenzene 

Downstream Products

• 916747-36-9 1,3,6-tris(5-tert-butyl-2-methoxyphenyl)pyrene 
• 866613-68-5 C₁₇H₁₉NO₂ 
• 1332625-70-3 6-bromo-6′-(2-methoxy-5-methylphenyl)-2,2′-bipyridine 
• 1332625-71-4 6-(5-tert-butyl-2-methoxyphenyl)-6'-(3-methoxynaphthalen-2-yl)-2,2'-bipyridine 
• 1332625-72-5 C₃₀H₂₆N₂O₂ 
• 1379680-59-7 C₄₄H₄₄O₂P₂ 
• 1379680-60-0 C₄₄H₄₄P₂ 
• 1609654-41-2 2-(5-(tert-butyl)-2-methoxyphenyl)-5-methylpyridine 
• 1609654-42-3 4-(tert-butyl)-2-(5-methylpyridin-2-yl)phenol 
• 1422465-68-6 1,4-bis(4,4′-di-tert-butylbiphenyl-2-yl)-2,5-dimethoxybenzene 
• 866613-69-6 C₁₆H₁₇NO₂ 
• 866613-67-4 C₂₈H₃₄N₂O 

Relevant academic research and scientific papers

HETEROARYL DERIVATIVES AND USES THEREOF

The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.

Aryl Derivatives And Uses Thereof

The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.

Stable axial chirality in metal complexes bearing 4,4′-substituted BIPHEPs: Application to catalytic asymmetric carbon-carbon bond-forming reactions

Not only electronic but also steric effects of 4,4′-substituents in BIPHEP derivatives and metal (Pd, Pt, and Au) complexes are shown to influence the stability of the biphenyl single bond rotation. While electron-donating or sterically demanding substituents on the 4,4′-positions destabilize the axial chirality of BIPHEP derivatives, electron-withdrawing or sterically less demanding ones on the 4,4′-positions stabilize the axis chirality. Particularly, the axial chirality of palladium dichloride complexes bearing BIPHEP with t-Bu and CF3 substituents on the 4,4′-positions is most labile and stable, respectively (ΔG≠ = 29.22 and 30.49 kcal mol-1 at 300 K; t1/2 = 7 and 56 years at 300 K). These enantiopure dicationic BIPHEPPd complexes can be employed for catalytic enantioselective arylation, alkenylation, and ene reactions to give the corresponding products in good-to-excellent yields and enantioselectivities. Significantly, in the carbonyl-ene reaction of trifluoropyruvate with isobutene, the turnover frequency (TOF) reached 58200 h-1. The remarkable effects of 4,4′-substituents in BIPHEP derivatives can be employed as a guiding principle in the design of versatile and efficient ligands.

CETP INHIBITORS

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B.