tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate
CAS No.:1428479-10-0
Molecular Formula:C₂₇H₃₂FN₃O₄
Molecular Weight:481.567
Hs Code.:

Synonyms:tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

: 100-51-6,185532-71-2
benzyl alcohol

: 1428479-10-0
tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

Guidance literature:: With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃; for 7.5h;

Reference yield:

: 1428478-56-1
1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

: 1428479-10-0
tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol; water / 72 h / 20 °C

2: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 7.5 h / 80 °C

With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1428479-10-0
tert-butyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]-4-[(benzyloxycarbonyl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 72 h / 20 °C

3.1: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7.5 h / 80 °C

With n-butyllithium; diphenylphosphoranyl azide; water; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane;