1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate
CAS No.:1428478-56-1
Molecular Formula:C₂₂H₂₉FN₂O₄
Molecular Weight:404.482
Hs Code.:

Synonyms:1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

There total 5 articles about 1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428478-55-0
5-(2-bromoethyl)-2-fluorobenzonitrile

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1428478-56-1
1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;

5-(2-bromoethyl)-2-fluorobenzonitrile; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

: 1428478-55-0
5-(2-bromoethyl)-2-fluorobenzonitrile

: 188792-67-8
1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid

: 1428478-56-1
1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

5-(2-bromoethyl)-2-fluorobenzonitrile; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

: 1428478-54-9
2-fluoro-5-(2-hydroxyethyl)benzonitrile

: 1428478-56-1
1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / -5 - 0 °C

1.2: 12 h / Reflux; Inert atmosphere

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

With n-butyllithium; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;