Ethyl 2-(2-ethoxy-4-formylphenoxy)acetate

Base Information

• Chemical Name: Ethyl 2-(2-ethoxy-4-formylphenoxy)acetate
• CAS No.: 51264-71-2
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267
• DSSTox Substance ID: DTXSID201270484
• Mol file: 51264-71-2.mol

Synonyms:ethyl 2-(2-ethoxy-4-formylphenoxy)acetate;ethyl (2-ethoxy-4-formylphenoxy)acetate;51264-71-2;Oprea1_122752;Oprea1_509776;SCHEMBL13858849;DTXSID201270484;BCA26471;MFCD02256180;STK346695;AKOS000178305;CS-0117466;EN300-227948;AB00108942-01;SR-01000235777;SR-01000235777-1;Z54068349

Chemical Property of Ethyl 2-(2-ethoxy-4-formylphenoxy)acetate

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 252.09977361
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

99% ^*data from raw suppliers

ETHYL (2-ETHOXY-4-FORMYLPHENOXY)ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=C(C=CC(=C1)C=O)OCC(=O)OCC

Technology Process of Ethyl 2-(2-ethoxy-4-formylphenoxy)acetate

There total 3 articles about Ethyl 2-(2-ethoxy-4-formylphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) + ethyl bromoacetate (105-36-2) → ethyl 2-(2-ethoxy-4-formylphenoxy)acetate (51264-71-2)

Guidance literature:

With potassium carbonate; at 50 ℃; for 5h;

DOI:10.3390/molecules21040396

Reference yield: 75.0%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(2-ethoxy-4-formylphenoxy)acetate (51264-71-2)

Guidance literature:

4-hydroxy-3-ethoxybenzaldehyde; With potassium carbonate; sodium iodide; In acetonitrile; for 0.5h; Reflux; Inert atmosphere;

chloroacetic acid ethyl ester; In acetonitrile; for 16h; Reflux; Inert atmosphere;

Reference yield: 63.0%

→ ethyl 2-(2-ethoxy-4-formylphenoxy)acetate (51264-71-2)

Guidance literature:

upstream raw materials:

4-hydroxy-3-ethoxybenzaldehyde

ethyl bromoacetate

chloroacetic acid ethyl ester