C₂₅H₃₂N₆O₂

Base Information

• Chemical Name: C₂₅H₃₂N₆O₂
• CAS No.: 1424432-36-9
• Molecular Formula: C₂₅H₃₂N₆O₂
• Molecular Weight: 448.568
• Mol file: 1424432-36-9.mol

Synonyms:C₂₅H₃₂N₆O₂

Chemical Property of C₂₅H₃₂N₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₂N₆O₂

There total 10 articles about C₂₅H₃₂N₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-chloro-pyridine-3-carboxamide (64321-24-0) → C25H32N6O2 (1424432-36-9)

Guidance literature:

Multi-step reaction with 7 steps

1: toluene / 115 °C

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 70 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol / 140 °C

6: methanesulfonyl chloride; triethylamine / dichloromethane / 20 °C

7: triethylamine; potassium carbonate / N,N-dimethyl-formamide / 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2013.01.019

Reference yield:

C24H28ClN5O2 + methylamine (74-89-5) → C25H32N6O2 (1424432-36-9)

Guidance literature:

With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; at 40 ℃;

DOI:10.1016/j.bmcl.2013.01.019

Reference yield:

2,6-dichloropyridine-3-carboxylic acid (38496-18-3) → C25H32N6O2 (1424432-36-9)

Guidance literature:

Multi-step reaction with 10 steps

1: ammonia / 130 °C / 13501.4 Torr

2: thionyl chloride / tetrahydrofuran / 20 °C

3: ammonia / tetrahydrofuran / 20 °C

4: toluene / 115 °C

5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 70 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol / 140 °C

9: methanesulfonyl chloride; triethylamine / dichloromethane / 20 °C

10: triethylamine; potassium carbonate / N,N-dimethyl-formamide / 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; ammonia; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2013.01.019

upstream raw materials:

2,6-dichloropyridine-3-carboxylic acid

2-amino-6-chloro-pyridine-3-carboxamide

7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

2,4,7-trichloropyrido[2,3-d]pyrimidine

Refernces