(3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

Base Information

Chemical Name:(3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one
CAS No.:301677-60-1
Molecular Formula:C₂₉H₃₈N₂O₅Si
Molecular Weight:522.717
Hs Code.:

Synonyms:(3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

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Chemical Property of (3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

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Technology Process of (3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

There total 6 articles about (3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 301677-59-8
7-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyridine 5-oxide

: 301677-62-3
(3aS,7S,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

: 301677-60-1
(3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

: (Benzhydrylidene-amino)-[(3aS,6S,7S,7aS)-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridin-6-yl]-acetic acid ethyl ester

Guidance literature:: ethyl N-diphenylmethylene glycine; With lithium hexamethyldisilazane; In toluene; at -78 ℃;

7-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyridine 5-oxide; In toluene; at -78 - 0 ℃;
DOI:10.1016/S0960-894X(00)00348-6

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 301677-60-1
(3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: TsOH / dimethylformamide

1.2: imidazole / CH₂Cl₂ / 0 - 25 °C

1.3: 11 percent / EtCO₂H / tetrahydrofuran / 60 °C

2.1: NEt₃; DMAP / CH₂Cl₂ / 0 - 25 °C

3.1: O₃ / ethyl acetate / -78 °C

3.2: 79 percent / Me₂S / -78 - 25 °C

4.1: 95 percent / NH₂OH*HCl; NEt₃ / ethanol / 25 °C

5.1: LiHMDS / toluene / -78 °C

5.2: 35 percent / toluene / -78 - 0 °C

With dmap; hydroxylamine hydrochloride; toluene-4-sulfonic acid; ozone; triethylamine; lithium hexamethyldisilazane; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: acetalization / 1.2: silylation / 1.3: olefination / 2.1: mesylation / 3.1: ozonolysis / 3.2: Reduction / 4.1: Condensation / 5.1: Metallation / 5.2: Cycloaddition;
DOI:10.1016/S0960-894X(00)00348-6

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: 301677-60-1
(3aS,7R,7aS,8S,8aS)-7-(Benzhydrylidene-amino)-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-hexahydro-1,3,5-trioxa-4a-aza-s-indacen-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: TsOH / dimethylformamide

1.2: imidazole / CH₂Cl₂ / 0 - 25 °C

1.3: 11 percent / EtCO₂H / tetrahydrofuran / 60 °C

2.1: NEt₃; DMAP / CH₂Cl₂ / 0 - 25 °C

3.1: O₃ / ethyl acetate / -78 °C

3.2: 79 percent / Me₂S / -78 - 25 °C

4.1: 95 percent / NH₂OH*HCl; NEt₃ / ethanol / 25 °C

5.1: LiHMDS / toluene / -78 °C

5.2: 35 percent / toluene / -78 - 0 °C

With dmap; hydroxylamine hydrochloride; toluene-4-sulfonic acid; ozone; triethylamine; lithium hexamethyldisilazane; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: acetalization / 1.2: silylation / 1.3: olefination / 2.1: mesylation / 3.1: ozonolysis / 3.2: Reduction / 4.1: Condensation / 5.1: Metallation / 5.2: Cycloaddition;
DOI:10.1016/S0960-894X(00)00348-6