Technology Process of 2-bromo-4-fluoro-6-(1-oxo-6,7,8,9-tetrahydropyridazino[4,5-b]indolizin-2(1H)-yl)benzaldehyde
There total 8 articles about 2-bromo-4-fluoro-6-(1-oxo-6,7,8,9-tetrahydropyridazino[4,5-b]indolizin-2(1H)-yl)benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate;
In
1,4-dioxane;
at 90 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane / chloroform / 48 h / 20 °C
2.1: acetic anhydride / 4 h / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / Inert atmosphere
4.1: trichlorophosphate / dichloromethane / 1.17 h / 0 - 20 °C
4.2: 3 h / 20 °C
5.1: hydrazine hydrate / 4 h / 100 °C
6.1: copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
With
1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline; palladium 10% on activated carbon; hydrogen; acetic anhydride; caesium carbonate; hydrazine hydrate; trichlorophosphate;
In
1,4-dioxane; methanol; dichloromethane; chloroform;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic anhydride / 4 h / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / Inert atmosphere
3.1: trichlorophosphate / dichloromethane / 1.17 h / 0 - 20 °C
3.2: 3 h / 20 °C
4.1: hydrazine hydrate / 4 h / 100 °C
5.1: copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
With
copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline; palladium 10% on activated carbon; hydrogen; acetic anhydride; caesium carbonate; hydrazine hydrate; trichlorophosphate;
In
1,4-dioxane; methanol; dichloromethane;
