1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene

Base Information

• Chemical Name: 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene
• CAS No.: 110450-79-8
• Molecular Formula: C₂₆H₅₂O₃Si₃
• Molecular Weight: 496.954
• Mol file: 110450-79-8.mol

Synonyms:1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene

Chemical Property of 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene

There total 2 articles about 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2′-(2,5-dihydrophenyl)ethanol (13398-95-3) + tert-butyldimethylsilyl chloride (18162-48-6) → 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene (110450-79-8)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; for 25h; from 0 deg C to room temperature;

DOI:10.1016/S0040-4039(00)85330-7

Reference yield:

5-Hydroxy-2-coumaranone (2688-48-4) → 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene (110450-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 3 h / -78 °C

2: 84 percent / triethylamine, 4-dimethylaminopyridine / dimethylformamide / 25 h / from 0 deg C to room temperature

With dmap; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(00)85330-7

Reference yield: 87.0%

1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene (110450-79-8) → 2-[2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethanol (110450-80-1)

Guidance literature:

With hydrogen fluoride; In dichloromethane; acetonitrile; for 1.8h; Ambient temperature;

DOI:10.1016/S0040-4039(00)85330-7

upstream raw materials:

2′-(2,5-dihydrophenyl)ethanol

tert-butyldimethylsilyl chloride

5-Hydroxy-2-coumaranone

Downstream raw materials:

2-[2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethanol

[2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde

cis-erbstatin

erbstatin