methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate

Base Information

• Chemical Name: methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate
• CAS No.: 329911-78-6
• Molecular Formula: C₂₅H₃₆N₄O₇
• Molecular Weight: 504.583
• Mol file: 329911-78-6.mol

Synonyms:methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate

Chemical Property of methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate

There total 7 articles about methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl glycyl-β-phenyl-β-alaninate hydrochloride + pentafluorophenyl 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoate (329911-76-4) → methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate (329911-78-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield:

methyl 3-amino-3-phenylpropionate hydrochloride (22838-46-6,88831-43-0,127022-80-4,144494-72-4) → methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate (329911-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1: DCCI; BtOH

2: HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane;

Reference yield:

methyl tert-butoxycarbonyl-glycyl-D,L-β-phenyl-β-alaninate (329911-77-5) → methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate (329911-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / dioxane

With hydrogenchloride; In 1,4-dioxane;

upstream raw materials:

pentafluorophenyl 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoate

4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid

3-(2-amino-acetylamino)-3-phenyl-propionic acid methyl ester

methyl 3-amino-3-phenylpropionate hydrochloride

Downstream raw materials:

(4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alanine