329911-77-5Relevant articles and documents
Synthesis and antiaggregation activity of a new RGDF peptidomimetic
Krys'ko,Kabanov,Polishchuk,Chugunov,Pavlovskii,Andronati,Mazepa,Kabanova,Karaseva
, p. 948 - 952 (2007/10/03)
A new RGDF peptidomimetic, [4-oxo-4-(pyperazin-1-yl)butyryl]glycyl-D,L-β-phenyl-β-alanine was synthesized. The arginyl mimetic used was the 4-oxo-4-(piperazin-1-yl)butanoic acid residue, and the Asp-Phe chain is replaced by a β-phenyl-β-alanine residue. The synthesized pseudopeptide showed ability to inhibite ADF-induced thrombocyte aggregation in a thrombocyte-rich rat blood plasma (IC50 8.7 × 10-9 M).