Synonyms:chlorosulfonic acid
99% *data from raw suppliers
Chlorosulfonic acid *data from reagent suppliers
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There total 75 articles about Chlorosulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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4-methoxycarbonylamino-benzenesulfonyl chloride
The research focuses on the development of a novel, cost-effective nanocatalyst, nano-sawdust-OSO3H, for the one-pot synthesis of biologically important pyrano[2,3-d]pyrimidines, which are known for their potential pharmaceutical applications such as antibacterial, antitumor, and analgesic activities. The experiments involved the use of reactants like barbituric acid or thiobarbituric acid, malononitrile, and a variety of aldehydes. The nanocatalyst was prepared by treating sawdust with chlorosulfonic acid, resulting in particles below 100 nm as observed through SEM imaging. The catalyst's morphology, chemical composition, thermal stability, and surface acidity were analyzed using techniques such as SEM, EDX, TGA/DTG, and FT-IR spectroscopy. The study demonstrated that nano-sawdust-OSO3H is an efficient catalyst, offering excellent yields in short reaction times and with mild reaction conditions, aligning with the principles of green chemistry.
The research focused on the acid catalysis of sulfamate group transfer reactions, which are of interest as a mild sulfonation method. The study aimed to investigate both intermolecular and intramolecular catalysis of sulfonate group transfer from sulfamates and to demonstrate the differences in these mechanisms. The researchers conducted experiments involving the hydrolysis of N-(2-carboxyphenyl)sulfamic acid and other related compounds, using various chemicals such as chlorosulfonic acid, 1-naphthylamine, Na2CO3, and dioxane/water as reaction media. They also utilized deuterium oxide for solvent isotope effects and performed kinetic measurements to analyze the reactions. The conclusions drawn from the study indicated that the carboxyl group participates in the hydrolysis of N-(2-carboxyphenyl)sulfamic acid, and that proton transfer from the carboxylic acid is concerted with sulfamate group transfer to water. The research also excluded neighboring nucleophilic attack on sulfur by the carboxylate group and demonstrated intermolecular catalysis by carboxylic acids in the hydrolysis of N-(1-naphthy1)sulfamic acid. The mechanism involved preequilibrium protonation of the nitrogen followed by nucleophilic attack on sulfur by the carboxylate anion, leading to the hydrolysis of the compound.
The study investigates a three-component reaction involving 5,5-dimethylcyclohexan-1,3-dione (dimedone), aromatic aldehydes, and acetonitrile in the presence of chlorosulfonic acid, resulting in the formation of N-[(2-hydroxy-4,4-dimethyl-6-oxocyclohexene-1-yl)-aryl-methyl]-acetamides. Dimedone acts as a dienophile, aromatic aldehydes serve as the Michael acceptors, and acetonitrile functions as the nucleophile in this reaction. Chlorosulfonic acid is used as a catalyst to promote the reaction. This method provides a straightforward and efficient route for synthesizing these acetamides in good yields, highlighting the utility of multicomponent reactions in generating structurally diverse compounds with potential biological and pharmaceutical relevance.
The research explores the development of a novel and efficient catalytic method for synthesizing 4,4'-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives using 1,3,5-tris(hydrogensulfato) benzene (THSB) as the catalyst. The study aims to address the limitations of existing methods, such as high costs, complex procedures, high temperatures, and long reaction times, by introducing a mild, efficient, and environmentally friendly alternative. Phloroglucinol (1,3,5-benzenetriol) is used as the starting material for the preparation of THSB. It reacts with chlorosulfonic acid to form the catalyst. Chlorosulfonic Acid is used to sulfonate phloroglucinol, resulting in the formation of THSB. It is a strong acid that provides the sulfato groups necessary for the catalytic activity of THSB. The results demonstrate that THSB effectively promotes the reaction, yielding high-quality products in excellent yields (90-98%) within short reaction times (2-5 minutes). The study concludes that the use of THSB offers significant advantages, including higher yields, milder reaction conditions, and shorter reaction times compared to other catalysts, making it a promising candidate for green chemistry applications. The researchers are further exploring the potential of THSB in other organic reactions.
This research aimed to develop an efficient, green, and one-pot synthesis method for 1,3-thiazolidin-4-one using a magnetically recyclable ionic liquid (ILs) supported on FeNi3 nanocatalyst. The purpose was to create a highly active and stable catalyst with high densities of functional groups under solvent-free conditions, utilizing rapid and easy immobilization techniques and low-cost precursors. The study successfully synthesized FeNi3-ILs nanoparticles, characterized them, and demonstrated their catalytic activity, achieving high to excellent yields of 1,3-thiazolidin-4-ones. The catalyst was found to be easily recoverable and reusable without significant loss of activity. Key chemicals used in the process included FeCl2·4H2O, NiCl2·6H2O, ammonium hydroxide, hydrazine hydrate, tetraethyl orthosilicate (TEOS), chlorosulfonic acid, and ethanolamine. The research concluded that FeNi3-ILs MNPs are a promising catalyst for the efficient one-pot synthesis of 1,3-thiazolidin-4-one and contribute to the development of new catalytic systems for organic synthesis.
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