6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

Base Information

Chemical Name:6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide
CAS No.:1365214-32-9
Molecular Formula:C₁₇H₁₇FN₆O
Molecular Weight:340.36
Hs Code.:

Synonyms:6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

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Chemical Property of 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

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Technology Process of 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

There total 4 articles about 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365212-62-9
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

: 1365214-32-9
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

Guidance literature:: With hydroxylamine; In ethanol; at 20 ℃; for 15h;

Reference yield:

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1365214-32-9
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 0.33 h

1.2: 72 h / 100 °C

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

3.1: hydroxylamine / ethanol / 15 h / 20 °C

With hydroxylamine; sodium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 1365214-32-9
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

2.1: sodium hydroxide / water / 0.33 h

2.2: 72 h / 100 °C

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

4.1: hydroxylamine / ethanol / 15 h / 20 °C

With N-Bromosuccinimide; hydroxylamine; sodium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;