6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

Base Information

Chemical Name:6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide
CAS No.:1365214-33-0
Molecular Formula:C₁₈H₁₉FN₆O
Molecular Weight:354.387
Hs Code.:

Synonyms:6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

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Chemical Property of 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

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Technology Process of 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

There total 5 articles about 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365214-32-9
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide

: 74-88-4
methyl iodide

: 1365214-33-0
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 17h;

Reference yield:

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1365214-33-0
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 0.33 h

1.2: 72 h / 100 °C

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

3.1: hydroxylamine / ethanol / 15 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 17 h / 75 °C

With hydroxylamine; caesium carbonate; sodium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1365212-61-8
(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

: 1365214-33-0
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

2: hydroxylamine / ethanol / 15 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 17 h / 75 °C

With hydroxylamine; caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide;