ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

Base Information

Chemical Name:ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate
CAS No.:191805-27-3
Molecular Formula:C₂₃H₃₃NO₅
Molecular Weight:403.519
Hs Code.:

Synonyms:ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

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Chemical Property of ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

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Technology Process of ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

There total 2 articles about ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65488-05-3
4-iodobutyrophenone

: 191805-27-3
ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Montmorillonite K-10 clay / 1.) RT, 20 min, 2.) toluene, RT, 16 h

2: 1.) potassium hexamethyldisilylamide / 1.) toluene, THF, 0 deg C, 0.5 h, 2.) toluene, THF, 4 h

With Montmorillonite K-10 clay; potassium hexamethylsilazane;
DOI:10.1021/jm970111h

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 191805-26-2
(4-iodo-1,1-dimethoxybutyl)benzene

: 191805-27-3
ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

Guidance literature:: With potassium hexamethylsilazane; Yield given. Multistep reaction; 1.) toluene, THF, 0 deg C, 0.5 h, 2.) toluene, THF, 4 h;
DOI:10.1021/jm970111h

Reference yield:

: 191805-27-3
ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate

: 191805-29-5
tert-butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate

: tert-butyl 2-benzoyl-1-oxo-8-azaspiro[4.5]decane-8-carboxate

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 ℃; for 1h; Yield given. Yields of byproduct given;
DOI:10.1021/jm970111h