N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

Base Information

Chemical Name:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline
CAS No.:1352608-83-3
Molecular Formula:C₂₂H₁₈FN₇
Molecular Weight:399.43
Hs Code.:

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

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Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

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Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

There total 6 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₁₆FN₇

: 1352608-83-3
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

Guidance literature:: In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 356560-84-4
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

: 1352608-83-3
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / methanol; tert-butyl methyl ether; water / 4 h / 20 °C

2: hydrogenchloride / water / 4 h / 70 °C

3: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

4: methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; acetic acid; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1352609-89-2
6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

: 1352608-83-3
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-fluoroaniline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 4 h / 70 °C

2: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

3: methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; acetic acid; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022