(E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one

Base Information

• Chemical Name: (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one
• CAS No.: 1174920-00-3
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.269
• Mol file: 1174920-00-3.mol

Synonyms:(E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one

Chemical Property of (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one

There total 6 articles about (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(4-acetylphenyl)-3-methyl-1-butyn-3-ol (95785-28-7) → (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one (1174920-00-3)

Guidance literature:

With chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; hydrogen; In dichloromethane; at 20 ℃; for 2.03333h; under 750.075 Torr; Schlenk technique;

DOI:10.1021/jacs.8b00665

Reference yield: 84.0%

(E)-1-((dibutyl(3-hydroxy-3-methylbut-1-en-1-yl)stannyl)hexyl)-3-ethyl-1H-imidazol-3-ium bromide (1441047-44-4,1441047-65-9) + para-bromoacetophenone (99-90-1) → (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one (1174920-00-3) + Br(1-)*C19H38BrN2Sn(1+) (1441047-57-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 130 ℃; for 24h;

DOI:10.1016/j.tet.2013.04.116

Reference yield: 39.0%

4-Iodoacetophenone (13329-40-3) + (E)-β-di-(3-hydroxy-3-methylbut-1-enyl)tetramethyldisiloxane (1263410-93-0) → (E)-1-(4-(3-hydroxy-3-methylbut-1-en-1-yl)phenyl)ethan-1-one (1174920-00-3)

Guidance literature:

With potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; at 50 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1039/c0ob00338g

upstream raw materials:

2-methyl-3-buten-2-ol

tridodecylamine

para-bromoacetophenone

C₁₇H₃₆GeO