tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate
CAS No.:1438386-21-0
Molecular Formula:C₃₂H₄₂N₆O₇S
Molecular Weight:654.787
Hs Code.:

tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

Synonyms:tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

There total 8 articles about tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1438386-16-3
tert-butyl 4-(4-azidophenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)piperidine-1-carboxylate

: 17573-94-3,752235-18-0
4-ethynyl-N,N-dimethylaniline

: 1438386-21-0
tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1039/c3ob41046c

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1438386-21-0
tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 48 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

4.1: palladium; hydrogen / ethanol / 72 h / 20 °C / 3102.97 Torr

5.1: trimethylsilylazide; tert.-butylnitrite / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 20 °C

7.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; water; hydrogen; benzotriazol-1-ol; palladium; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob41046c

Reference yield:

: 1438386-12-9
1-(tert-butoxycarbonyl)-4-(4-nitrophenylthio)piperidine-4-carboxylic acid

: 1438386-21-0
tert-butyl 4-(4-(4-(4-(dimethylamino)phenyl)-1H-1,2,3-triazol-1-yl)phenylsulfonyl)-4-(tetrahydro-2H-pyran-2-yloxycarbamoyl)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.1: palladium; hydrogen / ethanol / 72 h / 20 °C / 3102.97 Torr

3.1: trimethylsilylazide; tert.-butylnitrite / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

5.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; hydrogen; benzotriazol-1-ol; palladium; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob41046c