2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

Base Information

Chemical Name:2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate
CAS No.:1407978-27-1
Molecular Formula:C₂₀H₁₈ClFN₈O₂
Molecular Weight:456.867
Hs Code.:

Synonyms:2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

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Chemical Property of 2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

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Technology Process of 2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

There total 2 articles about 2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidine-4,5,6-triamine trihydrochloride

: 627-11-2
2-Chloroethyl chloroformate

: 1407978-27-1
2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 32h;

Reference yield:

: 1407978-23-7
2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

: 1407978-27-1
2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol; N,N-dimethyl-formamide / 18 h

2: pyridine / dichloromethane / 32 h / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield: 19.0%

: 64-18-6
formic acid

: 1407978-27-1
2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate

: 3-{4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}-1,3-oxazolidin-2-one formate

Guidance literature:: 2-chloroethyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

formic acid; In methanol; water;