N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

Base Information

Chemical Name:N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide
CAS No.:1436416-05-5
Molecular Formula:C₂₀H₂₅N₃O₃
Molecular Weight:355.437
Hs Code.:

Synonyms:N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

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Chemical Property of N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

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Technology Process of N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

There total 3 articles about N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1436416-04-4
N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

: 1436416-05-5
N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

: 1436416-06-6
C₁₆H₁₇N₃O₂

: 138713-44-7,74572-03-5
3-(-)-Phenyl morpholine

Guidance literature:: With urea hydrogen peroxide adduct; sodium hydroxide; In methanol; at 0 ℃; for 42h; Reagent/catalyst; Solvent; Concentration;
DOI:10.1021/op400101p

Reference yield:

: 127446-34-8
N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide

: 1436416-05-5
N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

: 1436416-06-6
C₁₆H₁₇N₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 100 °C

2: sodium hydroxide; urea hydrogen peroxide adduct / methanol / 42 h / 0 °C

With urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide; 2: |Dakin Phenol Oxidation;
DOI:10.1021/op400101p

Reference yield:

: 86847-84-9
2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide

: 1436416-05-5
N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

: 1436416-06-6
C₁₆H₁₇N₃O₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 2-methyltetrahydrofuran / 1 h / -40 - -25 °C / Inert atmosphere

1.2: 1.5 h / -15 - 15 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 100 °C

3.1: sodium hydroxide; urea hydrogen peroxide adduct / methanol / 42 h / 0 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 2-methyltetrahydrofuran; methanol; N,N-dimethyl-formamide; 3.1: |Dakin Phenol Oxidation;
DOI:10.1021/op400101p