N-(6-Chloro-3-formylpyridin-2-yl)pivalamide

Base Information

Chemical Name:N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
CAS No.:127446-34-8
Molecular Formula:C11H13ClN2O2
Molecular Weight:240.689
Hs Code.:2933399090
European Community (EC) Number:886-578-2
DSSTox Substance ID:DTXSID70563218
Nikkaji Number:J329.304A
Wikidata:Q72451625
Mol file:127446-34-8.mol

Synonyms:127446-34-8;N-(6-Chloro-3-formylpyridin-2-yl)pivalamide;N-(6-Chloro-3-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide;N-(6-Chloro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide;Propanamide, N-(6-chloro-3-formyl-2-pyridinyl)-2,2-dimethyl-;SCHEMBL247107;DTXSID70563218;QTIICTFBNRXNRF-UHFFFAOYSA-N;BCP27952;MFCD11846452;AKOS016009774;DS-2777;3-formyl-6-chloro-2-(pivaloylamino)pyridine;CS-0006541;EN300-6489832;Z1741981442

Suppliers and Price of N-(6-Chloro-3-formylpyridin-2-yl)pivalamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(6-Chloro-3-Formylpyridin-2-Yl)Pivalamide
100mg
$ 200.00

Matrix Scientific
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide 95+%
1g
$ 1296.00

Matrix Scientific
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide 95+%
250mg
$ 519.00

Crysdot
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide 97%
1g
$ 364.00

Crysdot
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide 97%
10g
$ 2475.00

Crysdot
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide 97%
5g
$ 1458.00

Chemenu
N-(6-chloro-3-formylpyridin-2-yl)pivalamide 97%
5g
$ 1376.00

Chemenu
N-(6-chloro-3-formylpyridin-2-yl)pivalamide 97%
1g
$ 344.00

Biosynth Carbosynth
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
1 g
$ 631.25

Biosynth Carbosynth
N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
100 mg
$ 105.00

Total 26 raw suppliers

Chemical Property of N-(6-Chloro-3-formylpyridin-2-yl)pivalamide

Chemical Property:

Melting Point:137-139℃
Boiling Point:428.644 °C at 760 mmHg
Flash Point:213.037 °C
PSA：59.06000
Density:1.274 g/cm³
LogP:2.60510
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:240.0665554
Heavy Atom Count:16
Complexity:276

Purity/Quality:

98% ^*data from raw suppliers

N-(6-Chloro-3-Formylpyridin-2-Yl)Pivalamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=C(C=CC(=N1)Cl)C=O

Technology Process of N-(6-Chloro-3-formylpyridin-2-yl)pivalamide

There total 4 articles about N-(6-Chloro-3-formylpyridin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 86847-84-9
2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 127446-34-8
N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide

Guidance literature:: 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - -10 ℃; for 2h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jm000148t

Reference yield: 54.0%

: 4394-85-8
4-morpholinecarboxaldehyde

: 86847-84-9
2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide

: 127446-34-8
N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide

Guidance literature:: 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In 2-methyltetrahydrofuran; at -40 - -25 ℃; for 1h; Inert atmosphere;

4-morpholinecarboxaldehyde; In 2-methyltetrahydrofuran; at -15 - 15 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/op400101p

Reference yield:

: 45644-21-1
6-chloropyridin-2-amine

: 127446-34-8
N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

2.1: BuLi; TMEDA / tetrahydrofuran; hexane / 2 h / -78 - -10 °C

2.2: 75 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1.1: Acylation / 2.1: Metallation / 2.2: Substitution;
DOI:10.1021/jm000148t