2-nitro-4-trifluoromethylbenzyl acetate

Base Information

• Chemical Name: 2-nitro-4-trifluoromethylbenzyl acetate
• CAS No.: 890434-87-4
• Molecular Formula: C₁₀H₈F₃NO₄
• Molecular Weight: 263.173
• Mol file: 890434-87-4.mol

Synonyms:2-nitro-4-trifluoromethylbenzyl acetate

Chemical Property of 2-nitro-4-trifluoromethylbenzyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-4-trifluoromethylbenzyl acetate

There total 1 articles about 2-nitro-4-trifluoromethylbenzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(chloromethyl)-2-nitro-4-(trifluoromethyl)benzene (225656-59-7) + sodium acetate (127-09-3) + acetic acid (64-19-7,77671-22-8) → 2-nitro-4-trifluoromethylbenzyl acetate (890434-87-4)

Guidance literature:

In water; at 20 - 100 ℃; for 60h;

Reference yield:

2-nitro-4-trifluoromethylbenzyl acetate (890434-87-4) → (2-nitro-4-(trifluoromethyl)phenyl)methanol (133605-27-3)

Guidance literature:

With methanol; sodium hydroxide; water; at 20 ℃; for 2h;

Reference yield:

2-nitro-4-trifluoromethylbenzyl acetate (890434-87-4) → 3-(4-[3-(2-Methoxymethyl-5-trifluoromethylphenyl)ureido]phenyl}-1H-indole-2-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol; sodium hydroxide; water / 2 h / 20 °C

2.1: silver(l) oxide / dichloromethane; water / 78 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 25 °C / 750.08 Torr

4.1: triethylamine / tetrahydrofuran; water / 1 h / 20 °C

4.2: 3 h / 20 °C

With methanol; sodium hydroxide; water; hydrogen; triethylamine; silver(l) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

1-(chloromethyl)-2-nitro-4-(trifluoromethyl)benzene

sodium acetate

acetic acid

Downstream raw materials:

(2-nitro-4-(trifluoromethyl)phenyl)methanol

2-methoxymethyl-5-trifluoromethylphenylamine

1-methoxymethyl-2-nitro-4-trifluoromethylbenzene

Refernces