2-chloro-3-nitrobenzoic acid ethylamide

Base Information

• Chemical Name: 2-chloro-3-nitrobenzoic acid ethylamide
• CAS No.: 117054-73-6
• Molecular Formula: C₉H₉ClN₂O₃
• Molecular Weight: 228.635
• Mol file: 117054-73-6.mol

Synonyms:2-chloro-3-nitrobenzoic acid ethylamide

Chemical Property of 2-chloro-3-nitrobenzoic acid ethylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-chloro-3-nitrobenzoic acid ethylamide

There total 1 articles about 2-chloro-3-nitrobenzoic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylamine (75-04-7,85404-22-4) + 2-chloro-3-nitrobezoic acid (3970-35-2) → 2-chloro-3-nitrobenzoic acid ethylamide (117054-73-6)

Guidance literature:

With thionyl chloride; Yield given. Multistep reaction; 2.) toluene;

DOI:10.1039/P29880000691

Reference yield: 55.0%

3-mercaptopropionitrile (1001-58-7) + 2-chloro-3-nitrobenzoic acid ethylamide (117054-73-6) → 2-(2-Cyano-ethylsulfanyl)-N-ethyl-3-nitro-benzamide (117054-74-7)

Guidance literature:

With lithium hydroxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 45 - 50 ℃; for 4h;

DOI:10.1039/P29880000691

Reference yield:

2-chloro-3-nitrobenzoic acid ethylamide (117054-73-6) → 2-(N-ethylcarbamoyl)-6-nitrothiophenol (117054-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / lithium hydroxide / hexamethylphosphoric acid triamide / 4 h / 45 - 50 °C

2: aq. NaOH / dioxane

With lithium hydroxide; sodium hydroxide; In 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1039/P29880000691

upstream raw materials:

ethylamine

2-chloro-3-nitrobezoic acid

Downstream raw materials:

2-(2-Cyano-ethylsulfanyl)-N-ethyl-3-nitro-benzamide

2-(N-ethylcarbamoyl)-6-nitrothiophenol