N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

Base Information

Chemical Name:N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide
CAS No.:202122-33-6
Molecular Formula:C₁₉H₂₀F₃NO₂
Molecular Weight:351.369
Hs Code.:

Synonyms:N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

Suppliers and Price of N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

There total 3 articles about N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 98-56-6
4-chlorobenzotrifluoride

: 202122-33-6
N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

: 56296-78-7
Adofen

Guidance literature:: 3-methylamino-1-phenylpropan-1-ol; N,N-dimethyl acetamide; 4-chlorobenzotrifluoride; With potassium hydroxide; In dimethyl sulfoxide; toluene; at 85 - 110 ℃; Large scale;

With hydrogenchloride; In isopropyl alcohol; at 75 ℃; for 2h; pH=2 - 3; Concentration; pH-value; Reagent/catalyst; Solvent; Temperature; Time; Thermodynamic data; Kinetics; Large scale;
DOI:10.1021/op400279n

Reference yield: 66.0%

: N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

: 402-43-7
p-trifluoromethylphenyl bromide

: 202122-33-6
N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

Guidance literature:: With nickel(II) bromide trihydrate; N-isopropyl-N-tert-butylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In acetonitrile; at 40 ℃; for 168h; Irradiation; Sealed tube;
DOI:10.1021/acs.orglett.9b01957

Reference yield:

: 98-86-2
acetophenone

: 202122-33-6
N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / acetone / 95 °C

2.1: palladium on activated charcoal; hydrogen / ethyl acetate

3.1: potassium hydroxide / dimethyl sulfoxide; toluene / 85 - 110 °C / Large scale

3.2: 2 h / 75 °C / pH 2 - 3 / Large scale

With hydrogenchloride; palladium on activated charcoal; hydrogen; potassium hydroxide; In dimethyl sulfoxide; ethyl acetate; acetone; toluene;
DOI:10.1021/op400279n