5-(p-Tolyl)pyridin-2-amine

Base Information

• Chemical Name: 5-(p-Tolyl)pyridin-2-amine
• CAS No.: 503536-74-1
• Molecular Formula: C12H12 N2
• Molecular Weight: 184.24
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70602414
• Wikidata: Q72495216
• Mol file: 503536-74-1.mol

Synonyms:5-(p-Tolyl)pyridin-2-amine;503536-74-1;5-p-Tolylpyridin-2-ylamine;5-(4-Methylphenyl)pyridin-2-amine;5-(4-Methylphenyl)-2-pyridinamine;5-p-tolylpyridin-2-amine;SCHEMBL12864338;DTXSID70602414;MFCD06797790;AKOS004116444;DS-0171;FS-2238;SB52316;DB-071175;CS-0187074;A871592

Chemical Property of 5-(p-Tolyl)pyridin-2-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 334.363oC at 760 mmHg
• Flash Point: 182.486oC
• PSA: 38.91000
• Density: 1.107g/cm3
• LogP: 3.22040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.100048391
• Heavy Atom Count: 14
• Complexity: 173

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Methylphenyl)pyridin-2-amine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CN=C(C=C2)N

Technology Process of 5-(p-Tolyl)pyridin-2-amine

There total 2 articles about 5-(p-Tolyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromo-2-pyridylamine (1072-97-5) + 4-methylphenylboronic acid (5720-05-8) → 5-(4-methylphenyl)pyridin-2-ylamine (503536-74-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 3h;

DOI:10.1016/j.bmcl.2017.07.072

Reference yield: 63.0%

N-[(3'-bromo-5'-(4''-methylphenyl))pyridin-2-yl]pyridinium aminide (910791-86-5) → 5-(4-methylphenyl)pyridin-2-ylamine (503536-74-1) + 3-(4''-methylphenyl)-dipyrido[1,2-b;3',2'-d]pyrazole (1087037-18-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In acetonitrile; benzene; for 32h;

DOI:10.1021/jo801549u

Reference yield: 74.0%

5-(4-methylphenyl)pyridin-2-ylamine (503536-74-1) + 1-(2-bromophenyl)-4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine] (1554015-91-6) → C36H41ClN4O (1609548-30-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 110 ℃; for 16h;

DOI:10.1016/j.bmcl.2014.04.011

upstream raw materials:

N-[(3'-bromo-5'-(4''-methylphenyl))pyridin-2-yl]pyridinium aminide

5-bromo-2-pyridylamine

4-methylphenylboronic acid

Downstream raw materials:

N-[5-(4-methylphenyl)pyridin-2-yl]benzamide

C₃₆H₄₁ClN₄O

3-bromo-5-(4-methylphenyl)-2-pyridinamine