(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

Base Information

Chemical Name:(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine
CAS No.:153923-56-9
Molecular Formula:C₁₆H₁₇NS
Molecular Weight:255.384
Hs Code.:

Synonyms:(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

Chemical Property:

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Technology Process of (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

There total 9 articles about (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 153923-52-5
(R)-3-benzyl-3,4-dihydrobenzo[f][1,4]thiazepin-5(2H)-one

: 153923-56-9
(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 30h; Reflux;

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 153923-56-9
(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 0 - 20 °C

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 4 h / 60 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

5.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 141595-88-2
(R)-tert-butyl (1-bromo-3-phenylpropan-2-yl)carbamate

: 153923-56-9
(R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 4 h / 60 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C

3.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;