(S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

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Chemical Name:(S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide
CAS No.:1352639-61-2
Molecular Formula:C₂₇H₃₀ClN₃O₅
Molecular Weight:512.005
Hs Code.:

Synonyms:(S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

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Chemical Property of (S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

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Technology Process of (S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

There total 6 articles about (S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.4%

: 1072-98-6
5-chloro-2-pyridylamine

: 1352639-55-4
(S)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionic acid

: 1352639-61-2
(S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

Guidance literature:: With 4-methyl-morpholine; HATU; In tetrahydrofuran; at 90 ℃; for 16h; Sealed tube;

Reference yield:

: 40056-18-6,789460-77-1
methyl L-cyclohexylalaninate

: 1352639-61-2
(S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 10 h / 25 °C / Molecular sieve

1.2: 16 h / 25 °C / Molecular sieve

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 140 °C / Sealed tube

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 25 °C

4.1: 4-methyl-morpholine; HATU / tetrahydrofuran / 16 h / 90 °C / Sealed tube

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 64466-51-9
3,6-Dimethoxy-2-hydroxybenzaldehyde

: 1352639-61-2
(S)-N-(5-chloro-pyridin-2-yl)-3-cyclohexyl-2-(5,8-dimethoxy-3-oxo-3,9-dihydro-1H-chromeno[2,3-c]pyrrol-2-yl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyrrolidine / dimethyl sulfoxide / 78 h / 25 °C

2.1: N-ethyl-N,N-diisopropylamine / methanol / 10 h / 25 °C / Molecular sieve

2.2: 16 h / 25 °C / Molecular sieve

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 140 °C / Sealed tube

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 25 °C

5.1: 4-methyl-morpholine; HATU / tetrahydrofuran / 16 h / 90 °C / Sealed tube

With pyrrolidine; 4-methyl-morpholine; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;