64466-51-9Relevant academic research and scientific papers
Synthesis of novel pyranoquinones using an acyl radical cyclization strategy
Donner, Christopher D.,Casana, Myriam I.
scheme or table, p. 1105 - 1107 (2012/04/10)
The thiol-catalysed cyclization of acyl radicals generated directly from benzaldehyde precursors has been investigated. Hindered β- benzyloxyacrylates cyclize efficiently providing a tin-free radical cyclization approach to the serine/threonine kinase AKT inhibitor frenolicin B, whilst γ-aryloxy crotonates give good yields of benzopyran-4-ones. This method is applied to the synthesis of a novel tetracyclic analogue of the pyranonaphthoquinone antibiotics.
LIQUID CRYSTAL COMPOUND COMPRISING TWO CONDENSED AND SUBSTITUTED RINGS
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Page/Page column 60-61, (2008/06/13)
A new liquid crystal compound comprises two condensed and substituted rings. The ring preferably is a five-membered heterocyclic ring. The heterocyclic ring is preferably condensed with benzene ring or an aromatic six-membered heterocyclic ring. The benzene ring or the aromatic six-membered heterocyclic ring is preferably substituted with a group comprising a cyclic structure and a chain structure. The liquid crystal compound is advantageously used in preparation of a thin phase retarder, such as a wide-ranged l/4 plate, which gives inverse wavelength distribution. The phase retarder can be easily produced according to a simple process by using the new liquid crystal compound.
Synthesis of the bisbenzannelated spiroketal core of the γ-rubromycins. The use of a novel Nef-type reaction mediated by Pearlman's catalyst
Capecchi, Tanya,De Koning, Charles B.,Michael, Joseph P.
, p. 2681 - 2688 (2007/10/03)
The synthesis of the bisbenzannelated spiroketal core 6 of γ-rubromycin 1 from the substituted nitrostyrene 20 was achieved by using a novel Nef-type reaction mediated by Pearlman's catalyst. The precursor 28 was synthesised from readily prepared starting materials using Henry condensation chemistry. The product 6 was found to exist in two conformations in solution as shown by NMR spectroscopy.
Nitroalkenes as precursors to the aromatic spiroketal skeleton of γ- rubromycin. A Nef-type reaction mediated by Pearlman's catalyst
Capecchi, Tanya,De Koning, Charles B.,Michael, Joseph P.
, p. 5429 - 5432 (2007/10/03)
The first synthesis of the benzannelated spiroketal core of γ- rubromycin using Henry condensations and a novel Nef-type reaction induced by Pearlman's catalyst is described.
A convenient preparation of salicylaldehydes from 2-methylbenzofurans by ozonolysis
Ishii,Ohia,Nashioka,Hayashida,Harayama
, p. 1166 - 1168 (2007/10/02)
A convenient and effective transformation of 2-methylbenzofuran (B) to salicylaldehyde (C) was achieved by ozonolysis of B in CH2Cl2 at -78°C followed by alkaline hydrolysis.
Synthetic studies on naturally occurring coumarins. I. A convenient synthesis of 5,8-dimethoxy- and 7,8-dimethoxycoumarins
Ishii,Kenmotsu,Dopke,Harayama
, p. 1770 - 1772 (2007/10/02)
The coumarin isolated from Artemisia carvifolia Wall was proved synthetically to be 7,8-dimethoxycoumarin and not 5,8-dimethoxycoumarin as previously proposed. 3,4-Dimethoxy- and 3,6-dimethoxysalicylaldehydes gave the corresponding coumarins in good yield by the method using phosphorane reagent in N,N-diethylaniline under reflux.
Synthesis of Halodimethoxy-1,2-benzoquinones
Wriede, Ulrich,Fernandez, Mario,West, Kevin F.,Harcourt, Dale,Moore, Harold W.
, p. 4485 - 4489 (2007/10/02)
Syntheses of a large number of halodimethoxy-1,2-benzoquinones are described.A key reaction in these syntheses is the chlorination of methoxy-1,2-benzoquinones upon treatment with tert-butyl hypochlorite.
