1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

Base Information

Chemical Name:1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine
CAS No.:1447274-36-3
Molecular Formula:C₂₄H₁₈F₆N₄
Molecular Weight:476.424
Hs Code.:

Synonyms:1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

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Chemical Property of 1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

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Technology Process of 1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

There total 5 articles about 1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1447274-43-2
tert-butyl (1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutyl)carbamate

: 1447274-36-3
1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1447274-36-3
1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate; sodium periodate / acetone / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 0.01 h / 110 °C / Microwave irradiation

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 0 - 20 °C

With hydrogenchloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; caesium carbonate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1447274-36-3
1-{4-[3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]phenyl}cyclobutanamine

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / tetrahydrofuran / 5 h / Reflux

2: ammonium acetate; sodium periodate / acetone / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 0.01 h / 110 °C / Microwave irradiation

4: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 0 - 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; potassium acetate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;