(2aR,3R,5S,5aR,8aR,8bR)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

Base Information

Chemical Name:(2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate
CAS No.:138175-77-6
Molecular Formula:C₂₈H₃₈O₇Si
Molecular Weight:514.691
Hs Code.:

(2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

Synonyms:(2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

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Chemical Property of (2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

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Technology Process of (2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

There total 17 articles about (2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (2aR*,3R*,5S*,5aR*,6S*,8aR*,8bR*)-methyl 6-benzoyloxy-3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)perhydronaphtho<1,8-bc>furan-2a-carboxylate

: 138175-77-6
(2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 2.25h; Ambient temperature;
DOI:10.1039/P19920002735

Reference yield: 100.0%

: 145745-86-4
(2aR*,3R*,5S*,5aR*,6S*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-6-pivaloyloxy-5a-(2'-pivaloyloxyethyl)perhydronaphtho<1,8-bc>furan-2a-carboxylate

: 138175-77-6
(2aR*,3R*,5S*,5aR*,8aR*,8bR*)-methyl 3-dimethyl(phenyl)silyl-5-hydroxy-8-oxo-5a-(2'-pivaloyloxyethyl)-4,5,5a,8,8a,8b-hexahydro-2H,3H-naphtho<1,8-bc>furan-2a-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 2.25h; Ambient temperature;
DOI:10.1039/P19920002735

Reference yield:

: 3282-30-2
pivaloyl chloride

: 138175-77-6
(2aR,3R,5S,5aR,8aR,8bR)-3-(Dimethyl-phenyl-silanyl)-5a-[2-(2,2-dimethyl-propionyloxy)-ethyl]-5-hydroxy-8-oxo-4,5,5a,8,8a,8b-hexahydro-3H-naphtho[1,8-bc]furan-2a-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / pyridine, DMAP / 45 °C

2: 96 percent / NaBH₄ / tetrahydrofuran; methanol

3: 1) MeI / 2) DBU / 1) CH₃CN, reflux

With pyridine; dmap; sodium tetrahydroborate; methyl iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol;
DOI:10.1016/0040-4039(91)80785-5