2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester
CAS No.:1448870-09-4
Molecular Formula:C₂₃H₂₁BrClFN₄O₂
Molecular Weight:519.801
Hs Code.:

Synonyms:2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

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Technology Process of 2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

There total 5 articles about 2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448869-83-7
2-bromo-5-[(4-cyano-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

: 2106-04-9
3-chloro-2-fluoroaniline

: 1448870-09-4
2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: 2-bromo-5-[(4-cyano-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester; With triethylamine; Methanesulfonic anhydride; In dichloromethane; at 5 ℃; for 0.5h; Inert atmosphere;

3-chloro-2-fluoroaniline; In dichloromethane; at 5 - 20 ℃; for 40h; Inert atmosphere;

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 1448870-09-4
2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 30 h / 20 °C / Inert atmosphere

2.1: butan-1-ol / 15 h / 130 °C / Inert atmosphere

3.1: N-Bromosuccinimide / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - 70 °C / Inert atmosphere

4.2: 1.5 h / -78 - -20 °C / Inert atmosphere

5.1: Methanesulfonic anhydride; triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere

5.2: 40 h / 5 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; triethylamine; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; ethanol; dichloromethane; butan-1-ol;

Reference yield:

: 1448869-67-7
2-bromo-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1448870-09-4
2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - 70 °C / Inert atmosphere

1.2: 1.5 h / -78 - -20 °C / Inert atmosphere

2.1: Methanesulfonic anhydride; triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere

2.2: 40 h / 5 - 20 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; dichloromethane;