Technology Process of 4-hydroxy-4-(4-methoxyphenyl)butanenitrile
There total 5 articles about 4-hydroxy-4-(4-methoxyphenyl)butanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia; water; zinc;
In
acetonitrile;
at 20 ℃;
for 20h;
under 760.051 Torr;
Sealed tube;
DOI:10.1002/adsc.201300073
- Guidance literature:
-
With
tris[2-phenylpyridinato-C2,N]iridium(III); N,N-dimethyl-formamide;
In
methanol;
at 20 ℃;
for 2h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b03707
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere
2: hydroxylamine hydrochloride; sodium acetate / methanol / 12 h / 75 °C / Inert atmosphere
3: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
4: tris[2-phenylpyridinato-C2,N]iridium(III); N,N-dimethyl-formamide / methanol / 2 h / 20 °C / Schlenk technique; Inert atmosphere
With
tris[2-phenylpyridinato-C2,N]iridium(III); hydroxylamine hydrochloride; sodium acetate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid;
In
methanol; dichloromethane;
DOI:10.1021/acs.orglett.7b03707
