(R)-(+)-p-chloro-N-acetyl-1-methylbenzylamine

Base Information

• Chemical Name: (R)-(+)-p-chloro-N-acetyl-1-methylbenzylamine
• CAS No.: 186296-21-9
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.664
• Mol file: 186296-21-9.mol

Synonyms:Acetamide,N-[1-(4-chlorophenyl)ethyl]-, (R)-

Chemical Property of (R)-(+)-p-chloro-N-acetyl-1-methylbenzylamine

Chemical Property:

• PSA: 32.59000
• Density: 1.136
• LogP: 3.37740

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(+)-p-chloro-N-acetyl-1-methylbenzylamine

There total 57 articles about (R)-(+)-p-chloro-N-acetyl-1-methylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-chlorophenyl)ethenylacetamide (208118-80-3) → (R)-N-[1-(4-chlorophenyl)ethyl]acetamide (92520-15-5,186296-21-9)

Guidance literature:

With BF4; hydrogen; In tetrahydrofuran; at 5 ℃; for 0.5h; under 760 Torr;

DOI:10.1021/ja974045k

Reference yield: 100.0%

1-(4-chlorophenyl)ethenylacetamide (208118-80-3) → (S)-N-[1-(4-chlorophenyl)ethyl]acetamide (186296-21-9)

Guidance literature:

With (S)-diBr-SIPHOS; hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; In toluene; at 0 ℃; for 30h; under 38000 Torr;

DOI:10.1016/j.tetasy.2003.08.017

Reference yield: 100.0%

hydrogen (1333-74-0) + 1-(4-chlorophenyl)ethenylacetamide (208118-80-3) → N-[1-(4-chlorophenyl)ethyl]acetamide (92520-15-5,186296-21-9)

Guidance literature:

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; C₃₄H₂₇F₄NP₂; In dichloromethane; at 20 ℃; for 24h; under 7600.51 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200800418

upstream raw materials:

1-(4-chlorophenyl)ethenylacetamide

(E)-1-(4-chlorophenyl)ethanone O-benzyl oxime

acetic anhydride

(E)-1-(4-chlorophenyl)ethanone oxime