carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester

Base Information

• Chemical Name: carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester
• CAS No.: 346433-57-6
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 346433-57-6.mol

Synonyms:carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester

Chemical Property of carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester

There total 6 articles about carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1-propenylbromide (3017-69-4) + 1-(hydroxy-methyl)-2,5-di-tert-butoxycarbonyloxy-benzene (288268-46-2) → carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester (346433-57-6)

Guidance literature:

2-methyl-1-propenylbromide; With magnesium; ethylene dibromide; In tetrahydrofuran; at 40 ℃; for 1h;

1-(hydroxy-methyl)-2,5-di-tert-butoxycarbonyloxy-benzene; In tetrahydrofuran; at 0 - 20 ℃; for 0.166667h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester (346433-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iPr₂NEt; DMAP / tetrahydrofuran / 10 h / 20 °C

2.1: Li(tBuO)3H / tetrahydrofuran

3.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 1 h / 40 °C

3.2: tetrahydrofuran / 0.17 h / 0 - 20 °C

With dmap; magnesium; lithium tri-t-butoxyaluminum hydride; ethylene dibromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde (288268-32-6) → carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester (346433-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Li(tBuO)3H / tetrahydrofuran

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 1 h / 40 °C

2.2: tetrahydrofuran / 0.17 h / 0 - 20 °C

With magnesium; lithium tri-t-butoxyaluminum hydride; ethylene dibromide; In tetrahydrofuran;

upstream raw materials:

2-methylpropen-1-ylmagnesium bromide

1-(hydroxy-methyl)-2,5-di-tert-butoxycarbonyloxy-benzene

2-methyl-1-propenylbromide

di-tert-butyl dicarbonate

Downstream raw materials:

3'-cyanobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

3'-methoxybiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

4-bromobenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester