N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide
CAS No.:1005780-91-5
Molecular Formula:C₁₆H₁₅N₅O₂
Molecular Weight:309.327
Hs Code.:

Synonyms:N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

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Chemical Property of N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

There total 1 articles about N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1005787-88-1
N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

: 123-30-8
4-amino-phenol

: 1005780-91-5
N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Guidance literature:: 4-amino-phenol; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide; With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 4h;
DOI:10.1016/j.bmc.2013.10.028

Reference yield: 70.0%

: 79-37-8
oxalyl dichloride

: 10199-57-2
5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1005780-91-5
N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

: 1005779-56-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

Guidance literature:: In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield: 65.0%

: 10199-57-2
5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1005780-91-5
N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

: 1005779-56-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

Guidance literature:: 5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.10.028