N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

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Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide
CAS No.:1005779-56-5
Molecular Formula:C₂₇H₂₃N₇O₃
Molecular Weight:493.525
Hs Code.:

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

There total 4 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 79-37-8
oxalyl dichloride

: 10199-57-2
5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1005780-91-5
N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

: 1005779-56-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

Guidance literature:: In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield: 65.0%

: 10199-57-2
5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1005780-91-5
N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

: 1005779-56-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

Guidance literature:: 5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.10.028

Reference yield:

: 1005787-88-1
N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

: 1005779-56-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 4 h / 140 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 2 h / 20 °C

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.10.028