Technology Process of 3-chloro-4-(6-methoxyquinolin-2-yl)benzoic acid
There total 4 articles about 3-chloro-4-(6-methoxyquinolin-2-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
water;
at 110 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic anhydride / 2 h / Reflux
2: trichlorophosphate / 2 h / Reflux
3: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere
With
2-(2-methoxyethoxy)ethyl alcohol; acetic anhydride; potassium carbonate; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dihydrogen peroxide / water; acetic acid / 21 h / 70 °C
1.2: pH 8 - 9
2.1: acetic anhydride / 2 h / Reflux
3.1: trichlorophosphate / 2 h / Reflux
4.1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere
With
2-(2-methoxyethoxy)ethyl alcohol; dihydrogen peroxide; acetic anhydride; potassium carbonate; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
water; acetic acid;
