1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Base Information

• Chemical Name: 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
• CAS No.: 680605-83-8
• Molecular Formula: C₁₅H₁₄N₂OS
• Molecular Weight: 270.355
• Mol file: 680605-83-8.mol

Synonyms:1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Chemical Property of 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

There total 8 articles about 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

thiophene boronic acid (6165-68-0) + 1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (1180009-36-2) → 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (680605-83-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; water; toluene; at 120 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jo9011859

Reference yield: 69.0%

3-phenyl-1-thiophen-2-yl-propenone (3988-77-0,39078-33-6,69656-36-6) + acetic acid hydrazide (1068-57-1) → 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (680605-83-8)

Guidance literature:

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In acetonitrile; at 60 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1039/b911577c

Reference yield: 56.0%

3-phenyl-1-thiophen-2-yl-propenone (3988-77-0,39078-33-6,69656-36-6) + acetic acid (64-19-7,77671-22-8) → 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (680605-83-8)

Guidance literature:

With hydrazine hydrate; Reflux;

DOI:10.1002/ardp.201400199

upstream raw materials:

thiophene boronic acid

1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

3-phenyl-1-thiophen-2-yl-propenone

acetic acid hydrazide

Downstream raw materials:

C₁₅H₁₂N₂OS