Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

Base Information

Chemical Name:Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate
CAS No.:1398571-15-7
Molecular Formula:C₂₅H₂₃Cl₂F₃N₂O₃
Molecular Weight:527.37
Hs Code.:

Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

Synonyms:Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

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Chemical Property of Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

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Technology Process of Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

There total 3 articles about Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 897365-76-3
(3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one

: 1398570-16-5
3,3-bis(fluoromethyl)cyclobutan-1-one

: 623-33-6
glycine ethyl ester hydrochloride

: 1398571-15-7
Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

Guidance literature:: 3,3-bis(fluoromethyl)cyclobutan-1-one; glycine ethyl ester hydrochloride; With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃; for 1h; Molecular sieve;

(3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃; for 32h;

Reference yield:

: 1023815-74-8
(3,3-dimethoxycyclobutane-1,1-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

: 1398571-15-7
Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 32 h / 50 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 13 h / 0 - 20 °C

3.1: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 70 °C / Molecular sieve

3.2: 32 h / 70 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; water; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1398570-15-4
1,1-Bis(fluoromethyl)-3,3-dimethoxycyclobutane

: 1398571-15-7
Ethyl (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2-oxo-1,2-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3-indole]-5'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 13 h / 0 - 20 °C

2.1: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 70 °C / Molecular sieve

2.2: 32 h / 70 °C

With hydrogenchloride; water; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;