(R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

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Chemical Name:(R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol
CAS No.:442663-43-6
Molecular Formula:C₃₈H₄₇NO₆Si
Molecular Weight:641.88
Hs Code.:

Synonyms:(R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

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Chemical Property of (R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

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Technology Process of (R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

There total 7 articles about (R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 442663-23-2
Trifluoro-methanesulfonic acid 7-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-ethyl]-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester

: 5158-46-3
methylzinc chloride

: 442663-43-6
(R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

Guidance literature:: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; for 4.5h; Heating;
DOI:10.1021/ja026216d

Reference yield:

: 533-31-3
Sesamol

: 442663-43-6
(R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

1.2: 97 percent / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0 - 20 °C

2.2: 92 percent / aq. H₂O₂; trimethylboronate; AcOH / tetrahydrofuran; hexane / 4.5 h / 20 °C

3.1: 89 percent / TFA / CH₂Cl₂ / 2.17 h / -10 °C

4.1: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

5.1: 85 percent / NaBH₄ / methanol / 0.5 h / 0 °C

6.1: 91 percent / imidazole / dimethylformamide / 20 °C

7.1: 97 percent / PdCl₂(dppf) / tetrahydrofuran / 4.5 h / Heating

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium hydride; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 3.1: Mannich reaction;
DOI:10.1021/ja026216d

Reference yield:

: 111726-43-3
3,4-(methylenedioxy)phenyl methoxymethyl ether

: 442663-43-6
(R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0 - 20 °C

1.2: 92 percent / aq. H₂O₂; trimethylboronate; AcOH / tetrahydrofuran; hexane / 4.5 h / 20 °C

2.1: 89 percent / TFA / CH₂Cl₂ / 2.17 h / -10 °C

3.1: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

4.1: 85 percent / NaBH₄ / methanol / 0.5 h / 0 °C

5.1: 91 percent / imidazole / dimethylformamide / 20 °C

6.1: 97 percent / PdCl₂(dppf) / tetrahydrofuran / 4.5 h / Heating

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 2.1: Mannich reaction;
DOI:10.1021/ja026216d