2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate

Base Information

• Chemical Name: 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate
• CAS No.: 79284-75-6
• Molecular Formula: C₅₂H₅₃N₂O₉PSSi
• Molecular Weight: 941.126
• Mol file: 79284-75-6.mol

Synonyms:2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate

Chemical Property of 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate

There total 4 articles about 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-diphenylmethylsilylethyl S-p-methoxyphenyl phosphorothioate (73364-59-7) + 5'-O-monomethoxytritylthymidine (42926-80-7,52474-36-9,124680-51-9,132970-00-4) → 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate (79284-75-6)

Guidance literature:

With TPS; In pyridine;

DOI:10.1016/S0040-4039(01)93285-X

Reference yield:

diphenylmethylsilylethylethanol (40438-48-0) → 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate (79284-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: TPS / pyridine

2: H₂O, NaOH / dioxane / 0.5 h / Ambient temperature

3: 92 percent / TPS / pyridine

With sodium hydroxide; water; In 1,4-dioxane; pyridine;

DOI:10.1016/S0040-4039(01)93285-X

Reference yield:

S, S'-di-p-methoxy-phenyl phosphorodithioate → 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate (79284-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: TPS / pyridine

2: H₂O, NaOH / dioxane / 0.5 h / Ambient temperature

3: 92 percent / TPS / pyridine

With sodium hydroxide; water; In 1,4-dioxane; pyridine;

DOI:10.1016/S0040-4039(01)93285-X

upstream raw materials:

2-diphenylmethylsilylethyl S-p-methoxyphenyl phosphorothioate

5'-O-monomethoxytritylthymidine

diphenylmethylsilylethylethanol

Dithiophosphoric acid S,S'-bis-(4-methoxy-phenyl) ester O-[2-(methyl-diphenyl-silanyl)-ethyl] ester

Downstream raw materials:

Thiophosphoric acid O-[(2S,3R,5S)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-methoxy-phenyl) ester O'-[2-(methyl-diphenyl-silanyl)-ethyl] ester