tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

Base Information

• Chemical Name: tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate
• CAS No.: 1439393-52-8
• Molecular Formula: C₁₉H₂₂ClN₅O₄
• Molecular Weight: 419.868

Synonyms:tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

Chemical Property of tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

Chemical Property:

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Technology Process of tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

There total 1 articles about tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.5%

4,6-dichloro-5-nitropyrimidine (4316-93-2) + [1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester (1259224-00-4) → tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate (1439393-52-8)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 3h; Temperature; Time; Inert atmosphere;

Reference yield: 93.0%

tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate (1439393-52-8) → tert-butyl 1-(4-(5-amino-6-chloropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate (1439393-54-0)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 20 ℃; for 1h; Temperature; Time; Inert atmosphere;

Reference yield:

tert-butyl 1-(4-(6-chloro-5-nitropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate (1439393-52-8) + dimethyl amine (124-40-3) → {1-[4-(6-dimethylamino-5-nitro-pyrimidin-4-ylamino)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (1439393-62-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

4,6-dichloro-5-nitropyrimidine

[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

Downstream raw materials:

tert-butyl 1-(4-(5-amino-6-chloropyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

tert-butyl 1-(4-(6-chloro-8-phenyl-9H-purin-9-yl)phenyl)cyclobutylcarbamate

{1-[4-(5-amino-6-dimethylamino-pyrimidin-4-ylamino)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

{1-[4-(6-dimethylamino-8-phenyl-purin-9-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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