[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid

Base Information

• Chemical Name: [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid
• CAS No.: 948317-75-7
• Molecular Formula: C₁₈H₁₉NO₉P₂
• Molecular Weight: 455.298
• Mol file: 948317-75-7.mol

Synonyms:[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid

Chemical Property of [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid

There total 4 articles about [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

dimethyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyryl]phosphonate (125040-04-2) + phenyl bis(trimethylsilyl) phosphite (137862-40-9) → [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid (948317-75-7)

Guidance literature:

dimethyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyryl]phosphonate; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 6h;

phenyl bis(trimethylsilyl) phosphite; at 20 ℃; Further stages.;

DOI:10.1002/ejoc.200601067

Reference yield:

phthalic anhydride (85-44-9) → [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid (948317-75-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / 6 h / 170 °C

2.1: 100 percent / oxalyl chloride / CH₂Cl₂ / 6 h / Heating

3.1: 100 percent / 2 h / 20 °C

4.1: bromotrimethylsilane / CH₂Cl₂ / 6 h / 20 °C

4.2: 58 percent / 20 °C

With oxalyl dichloride; trimethylsilyl bromide; In dichloromethane;

DOI:10.1002/ejoc.200601067

Reference yield:

4-phthalimidobutyryl chloride (10314-06-4) → [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid (948317-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / 2 h / 20 °C

2.1: bromotrimethylsilane / CH₂Cl₂ / 6 h / 20 °C

2.2: 58 percent / 20 °C

With trimethylsilyl bromide; In dichloromethane;

DOI:10.1002/ejoc.200601067

upstream raw materials:

dimethyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyryl]phosphonate

phenyl bis(trimethylsilyl) phosphite

phthalic anhydride

4-phthalimidobutyryl chloride