Phenyl bis(trimethylsilyl) phosphite

Base Information

• Chemical Name: Phenyl bis(trimethylsilyl) phosphite
• CAS No.: 137862-40-9
• Molecular Formula: C12H23O3PSi2
• Molecular Weight: 302.458
• DSSTox Substance ID: DTXSID10567876
• Nikkaji Number: J2.212.558C
• Wikidata: Q82453915
• Mol file: 137862-40-9.mol

Synonyms:Phenyl bis(trimethylsilyl) phosphite;137862-40-9;DTXSID10567876

Chemical Property of Phenyl bis(trimethylsilyl) phosphite

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 302.09233466
• Heavy Atom Count: 18
• Complexity: 229

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)OP(OC1=CC=CC=C1)O[Si](C)(C)C

Technology Process of Phenyl bis(trimethylsilyl) phosphite

There total 3 articles about Phenyl bis(trimethylsilyl) phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Phenyl phosphite ammonium salt (54921-72-1) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → phenyl bis(trimethylsilyl) phosphite (137862-40-9)

Guidance literature:

at 90 ℃; for 2h;

DOI:10.1016/j.tet.2005.05.053

Reference yield: 43.0%

N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) + phenyl phosphorodichloridite (3426-89-9) → phenyl bis(trimethylsilyl) phosphite (137862-40-9)

Guidance literature:

at 120 ℃; for 1h;

Reference yield:

diphenyl hydrogen phosphite (4712-55-4) → phenyl bis(trimethylsilyl) phosphite (137862-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / aq. NH₃ / 2 h / 20 °C

2: 45 percent / 2 h / 90 °C

With ammonium hydroxide;

DOI:10.1016/j.tet.2005.05.053

upstream raw materials:

N,O-bis-(trimethylsilyl)-acetamide

phenyl phosphorodichloridite

Phenyl phosphite ammonium salt

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate

monophenyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonate

monophenyl [6-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)hexyl]phosphonate

[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid