137862-40-9

Upstream product

• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 3426-89-9 phenyl phosphorodichloridite 
• 54921-72-1 Phenyl phosphite ammonium salt 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 4712-55-4 diphenyl hydrogen phosphite 

Downstream Products

• 948317-75-7 [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonic acid 
• 948317-85-9 monophenyl [6-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)hexyl]phosphonate 
• 948317-84-8 monophenyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)butyl]phosphonate 
• 948317-83-7 monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate 

Relevant academic research and scientific papers

Bisphosphonate prodrugs: Synthesis of new aromatic and aliphatic 1-hydroxy-1,1-bisphosphonate partial esters

Methods for the preparation of various 1-hydroxy-1,1-bisphosphonate partial esters were developed. They were obtained from (alkyl or phenyl) bis(trimethylsilyl) phosphite and aromatic or aliphatic acid chlorides, followed by methanolysis.

PHOSPHORYLATION OF DISILYLATED CARBOXAMIDES

The reaction of phosphorus(III) acid chlorides and dichlorides with disilylated carboxamides leads to the formation of mono- and bis-(trimethylsilyl)phosphites.The reactions of diethyl phosphorochloridate, O,O-diethyl phosphorochloridothioate, methylphosphonic dichloride, and phosphoryl chloride with disilylated acetamide proceed with the replacement of chlorine atoms by trimethylsiloxy groups.It was shown that β breakdown can occur in the P(S)-N=P-OSiMe3.