(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

Base Information

Chemical Name:(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate
CAS No.:1016652-34-8
Molecular Formula:C₂₄H₃₃NO₃Si
Molecular Weight:411.616
Hs Code.:

Synonyms:(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

Suppliers and Price of (S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

There total 1 articles about (S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 851592-08-0
(3Z)-(2S)-1-(tert-butyldimethylsilyloxy)-6-phenylhex-3-en-2-ol

: 98-98-6
2-Picolinic acid

: 1016652-34-8
(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1021/ol800300x

Reference yield: 93.0%

: 1016652-34-8
(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

: 100-58-3
phenylmagnesium bromide

: 1016652-49-5
(S,E)-1-[(tert-butyldimethylsilyl)oxy]-4,6-diphenyl-2-hexene

Guidance literature:: phenylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; Cooling with ice;

(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate; In tetrahydrofuran; at -60 - -40 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol800300x

Reference yield: 92.0%

: 1016652-34-8
(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate

: 925-90-6
ethylmagnesium bromide

: 1124260-40-7
(S,E)-1-[(tert-butyldimethylsilyl)oxy]-4-ethyl-6-phenyl-2-hexene

Guidance literature:: ethylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at 60 ℃;

(S,Z)-1-[(tert-butyldimethylsilyl)oxy]-6-phenylhex-3-en-2-yl pyridine-2-carboxylate; In tetrahydrofuran; at -60 - -40 ℃; optical yield given as %ee; stereoselective reaction;
DOI:10.1021/jo802426g