allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

Base Information

Chemical Name:allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate
CAS No.:1643461-51-1
Molecular Formula:C₃₄H₄₆N₂O₅
Molecular Weight:562.75
Hs Code.:

Synonyms:allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

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Chemical Property of allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

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Technology Process of allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

There total 5 articles about allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: allyl Indole-5-carboxylate

: 1643461-50-0
2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

: 1643461-51-1
allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

Guidance literature:: allyl Indole-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 3h;
DOI:10.1039/c4ob00535j

Reference yield:

: 1643461-49-7
tert-butyl [1-hydroxy-3-(4-octylphenoxy)propan-2-yl]carbamate

: 1643461-51-1
allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 3 h / 80 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j

Reference yield:

: 1806-26-4
p-Octylphenol

: 1643461-51-1
allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl}indole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 3 h / 70 °C

2.1: hydrogenchloride / methanol; diethyl ether / 12 h / 20 °C

3.1: triethylamine / methanol; diethyl ether / 12 h / 0 °C

4.1: dmap; triethylamine / dichloromethane / 12 h

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 3 h / 80 °C

With hydrogenchloride; dmap; sodium hydride; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j