(2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

Base Information

Chemical Name:(2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane
CAS No.:218797-66-1
Molecular Formula:C₂₁H₃₇NO₃Si
Molecular Weight:379.615
Hs Code.:

Synonyms:(2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

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Technology Process of (2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

There total 5 articles about (2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 218797-66-1
(2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / -15 - 23 °C

3: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature

4: 1.) CuI / 1.) diethyl ether, 0 deg C, 2.) diethyl ether, 2 h

With 1H-imidazole; dmap; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981140i

Reference yield:

: 125414-45-1
(2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

: 218797-66-1
(2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / -15 - 23 °C

3: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature

4: 1.) CuI / 1.) diethyl ether, 0 deg C, 2.) diethyl ether, 2 h

With 1H-imidazole; dmap; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981140i

Reference yield:

: 153704-74-6
(2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol

: 218797-66-1
(2S,3S)-1-<(tert-butyldimethylsilyl)oxy>-2-<(tert-butoxycarbonyl)amino>-3-phenylbutane

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / -15 - 23 °C

2: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature

3: 1.) CuI / 1.) diethyl ether, 0 deg C, 2.) diethyl ether, 2 h

With dmap; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo981140i