(-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

Base Information

Chemical Name:(-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone
CAS No.:334756-38-6
Molecular Formula:C₁₈H₂₅NO₃S
Molecular Weight:335.467
Hs Code.:

Synonyms:(-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

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Technology Process of (-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

There total 5 articles about (-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-36-5
acetyl chloride

: 334757-17-4
(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

: 334756-38-6
(-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; methylbutane; cyclohexane; 1.) -78 deg C, 2 h, 2.) -78 deg C;
DOI:10.1002/anie.199727841

Reference yield: 80.0%

: (3R)-3-Phenyl-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanol

: 334756-38-6
(-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y

Reference yield:

: 108-24-7
acetic anhydride

: 334757-17-4
(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

: 334756-38-6
(-)-(R)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-2-butanone

: (S)-3-Phenyl-3-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-thio)-2-butanone

Guidance literature:: (-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 2h;

acetic anhydride; In diethyl ether; cyclohexane; at -78 ℃; Further stages.;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y