(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

Base Information

Chemical Name:(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate
CAS No.:334757-17-4
Molecular Formula:C₁₆H₂₃NO₂S
Molecular Weight:293.43
Hs Code.:

Synonyms:(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

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Chemical Property of (-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

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Technology Process of (-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

There total 2 articles about (-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 33877-11-1
(S)-1-mercapto-1-phenylethane

: 146176-60-5
2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride

: 334757-17-4
(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

Guidance literature:: (S)-1-mercapto-1-phenylethane; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride; In tetrahydrofuran; for 3h; Further stages.; Heating;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y

Reference yield:

: 62258-06-4,67385-07-3,133098-85-8
thioacetic acid S-((S)-1-phenylethyl) ester

: 334757-17-4
(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3.75 g / LiAlH₄ / diethyl ether / 2 h / Heating

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: 97 percent / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y

Reference yield: 99.0%

: 334757-17-4
(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

: (-)-(S)-S-1-Deutero-1-phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

Guidance literature:: (-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 2h;

With deuteromethanol; In diethyl ether; cyclohexane; at -78 ℃; Further stages.;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y