2-BUTYL PYRAZINE

Base Information

• Chemical Name: 2-BUTYL PYRAZINE
• CAS No.: 29460-91-1
• Molecular Formula: C8H12N2
• Molecular Weight: 136.19
• Hs Code.: 2933990090
• Mol file: 29460-91-1.mol

Synonyms:Pyrazine,butyl- (7CI,8CI,9CI);2-Butylpyrazine;Butylpyrazine;

Chemical Property of 2-BUTYL PYRAZINE

Chemical Property:

• Boiling Point: 197.9 °C at 760 mmHg
• PKA: 1.67±0.10(Predicted)
• Flash Point: 73.5 °C
• PSA: 25.78000
• Density: 0.961 g/cm³
• LogP: 1.81920
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Butylpyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BUTYL PYRAZINE

There total 6 articles about 2-BUTYL PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,4-pyrazine (290-37-9) + valeric acid (109-52-4) → 2-Butylpyrazine (29460-91-1)

Guidance literature:

With ammonium persulfate; trifluoroacetic acid; silver nitrate; In water; chlorobenzene; for 2h; Heating;

DOI:10.1016/S0040-4020(01)82033-0

Reference yield: 27.0%

methyl pyrazine-2-carboxylate (6164-79-0) + butyl magnesium bromide (693-04-9) + 2-iodopyrazine (32111-21-0) → 2-Butylpyrazine (29460-91-1) + di-2-pyrazinylmethanone (1021298-90-7)

Guidance literature:

butyl magnesium bromide; 2-iodopyrazine; In tetrahydrofuran; at 0 ℃;

methyl pyrazine-2-carboxylate; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.tet.2011.09.133

Reference yield:

2-chloropyrazin (14508-49-7) + butyl magnesium bromide (693-04-9) → 2-Butylpyrazine (29460-91-1)

Guidance literature:

2-chloropyrazin; With MnCl₂(THF)_1.6; In tetrahydrofuran; at 21 ℃; for 0.0833333h; Glovebox; Inert atmosphere;

butyl magnesium bromide; In tetrahydrofuran; at 21 ℃; for 0.25h; Glovebox; Inert atmosphere;

DOI:10.1055/s-0037-1610200

upstream raw materials:

1,4-pyrazine

n-butyllithium

valeric acid

methyl pyrazine-2-carboxylate

Downstream raw materials:

6-(4-methoxyphenyl)-7-propyl[5H]pyrrolo[2,3-b]-pyrazine

Refernces

• 1、 Bloch, Witold M.,Derwent-Smith, Stephanie M.,Issa, Fatiah,Morris, Jonathan C.,Rendina, Louis M.,Sumby, Christopher J.. "Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties". scheme or table. p. 9368 - 9375. Retrieved 2011/12/03.